E-mail

E-mail a Wiley Online Library Link

Christopher O. Campbell, Daniel N. Santiago, Wayne C. Guida, Roman Manetsch and John H. Adams In silico Characterization of an Atypical MAPK Phosphatase of Plasmodium falciparum as a Suitable Target for Drug Discovery Chemical Biology & Drug Design 84

Article first published online: 12 MAY 2014 | DOI: 10.1111/cbdd.12315

Thumbnail image of graphical abstract

Forward genetic analysis of Plasmodium falciparum identified an atypical MAPK phosphatase expressed from PF3D7_1305500 as important for intraerythrocytic development. A homology model of the DUSP domain was used in high-throughput in silico screening of the available library of antimalarial compounds from ChEMBL-NTD, and three had reduced activity against a ∆PF3D7_1305500 parasite, suggesting PF3D7_1305500 is a potential target of the selected compounds. Our data suggest that the atypical MAPK phosphatase represents a potentially new type of P. falciparum drug target.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

SEARCH