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Christopher O. Campbell, Daniel N. Santiago, Wayne C. Guida, Roman Manetsch and John H. Adams In silico Characterization of an Atypical MAPK Phosphatase of Plasmodium falciparum as a Suitable Target for Drug Discovery Chemical Biology & Drug Design 84

Article first published online: 12 MAY 2014 | DOI: 10.1111/cbdd.12315

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Forward genetic analysis of Plasmodium falciparum identified an atypical MAPK phosphatase expressed from PF3D7_1305500 as important for intraerythrocytic development. A homology model of the DUSP domain was used in high-throughput in silico screening of the available library of antimalarial compounds from ChEMBL-NTD, and three had reduced activity against a ∆PF3D7_1305500 parasite, suggesting PF3D7_1305500 is a potential target of the selected compounds. Our data suggest that the atypical MAPK phosphatase represents a potentially new type of P. falciparum drug target.

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