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Paula Barrionuevo, M. Victoria Delpino, Roberto G. Pozner, Lis N. Velásquez, Juliana Cassataro and Guillermo H. Giambartolomei Brucella abortus induces intracellular retention of MHC-I molecules in human macrophages down-modulating cytotoxic CD8+ T cell responses Cellular Microbiology 15

Article first published online: 21 NOV 2012 | DOI: 10.1111/cmi.12058

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A vexing enigma of Brucella immunity is its long-term persistence in the host despite a vigorous and specific immune response. Our study describes a novel immune evasion mechanism whereby B. abortus down-modulates the expression of IFN-γ-induced MHC-I molecules in the surface of infected macrophages by sequestering them within the Golgi apparatus which correlates with a diminished CD8+ cytotoxic T cell response. These results provide new insights about how B. abortus is able to persist in its hosts in the presence of immune CD8+ T cells, establishing a chronic infection.

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