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Maria Podinovskaia, Wonsik Lee, Shannon Caldwell and David G. Russell Infection of macrophages with Mycobacterium tuberculosis induces global modifications to phagosomal function Cellular Microbiology 15

Version of Record online: 9 JAN 2013 | DOI: 10.1111/cmi.12092

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The ability to survive in macrophages is key to the success of Mycobacterium tuberculosis as a pathogen. While it is known that the bacterium modulates the behavior of the vacuole in which it resides, the impact of infection on the physiology of other phagosomes has yet to be fully elucidated. This current study demonstrates that Mtb infection selectively modulates phagosome function, most specifically down-regulating lipolysis, which likely contributes to the cell's increased retention of lipids that may be metabolized by the bacterium.

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