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J. M. M. Howson, M. S. Roy, L. Zeitels, H. Stevens and J. A. Todd HLA class II gene associations in African American Type 1 diabetes reveal a protective HLA-DRB1*03 haplotype Diabetic Medicine 30

Article first published online: 21 MAR 2013 | DOI: 10.1111/dme.12148

What's new?

  • This is the largest study in African Americans with Type 1 diabetes to date and the only study to account for ancestry.
  • This is the only study to date that fine maps the HLA region in African American samples using a dense map of 5147 single nucleotide polymorphisms and the class II genes.
  • We find HLA Type 1 diabetes associations that agree with known associations in Europeans, and novel associations of African ancestry specific alleles, e.g. HLA-DRB1*03:02, which confers protection from Type 1 diabetes.

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