Michelle L. Starkey, Katalin Bartus, Andrew W. Barritt and Elizabeth J. Bradbury Chondroitinase ABC promotes compensatory sprouting of the intact corticospinal tract and recovery of forelimb function following unilateral pyramidotomy in adult mice European Journal of Neuroscience 36
Unilateral injury of the corticospinal tract leads to impaired function in the denervated forelimb. The enzyme chondroitinase ABC (ChABC) reduces inhibitory extracellular matrix molecules. Treatment with this enzyme leads to restored function in the denervated forepaw and is associated with compensatory sprouting of intact corticospinal tract axons, which cross the midline into the denervated spinal cord. ChABC treatment is a potential therapy for disorders such as spinal cord injury and stroke.
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