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Mitsuhiro Fukuda, Alberto L. Vazquez, Xiaopeng Zong and Seong-Gi Kim Effects of the α2-adrenergic receptor agonist dexmedetomidine on neural, vascular and BOLD fMRI responses in the somatosensory cortex European Journal of Neuroscience 37

Article first published online: 29 OCT 2012 | DOI: 10.1111/ejn.12024

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This paper describes the effects of dexmedetomidine (DEX) the active ingredient of medetomidine which is the latest popular sedative for functional magnetic resonance imaging (fMRI) in rodents on multiple unit activity, local field potential (LFP), cerebral blood flow (CBF), pial vessel diameter (indicative of cerebral blood volume; CBV), and blood-oxygenation-level-dependent (BOLD) fMRI. These measurements were obtained from the rat somatosensory cortex during 10-s forepaw stimulation.

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