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Kathryn K. Walder, Steve B. Ryan, Tomasz Bzdega, Rafal T. Olszewski, Joseph H. Neale and Clark A. Lindgren Immunohistological and electrophysiological evidence that N-acetylaspartylglutamate is a co-transmitter at the vertebrate neuromuscular junction European Journal of Neuroscience 37

Version of Record online: 8 NOV 2012 | DOI: 10.1111/ejn.12027

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We present electrophysiological and immunohistological evidence that NAAG, one of the most abundant peptides in the mammalian CNS, is a co-transmitter at the vertebrate neuromuscular junction (NMJ). We show that all of the components associated with NAAGergic transmission in the CNS are present at the NMJ, including NAAG, its inactivating enzyme, and its receptor (mGluR3). Moreover, nerve stimulation depletes presynaptic NAAG and application of exogenous NAAG depresses evoked ACh release.

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