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Ruifeng Cao, Greg Q. Butcher, Kate Karelina, J. Simon Arthur and Karl Obrietan Mitogen- and stress-activated protein kinase 1 modulates photic entrainment of the suprachiasmatic circadian clock European Journal of Neuroscience 37

Article first published online: 6 NOV 2012 | DOI: 10.1111/ejn.12028

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Signaling via the ERK/MAPK pathway appears to play a central role in light-evoked circadian clock entrainment; however, the precise downstream mechanisms by which this pathway influences clock timing are not known. Here we show that the downstream ERK effector kinase MSK1 functions as a key signaling intermediate that couples ERK/MAPK signaling to photic resetting of the clock. These effects appear to be mediated in part by the stimulation of CREB, histone phosphorylation and, ultimately, the induction of core clock gene period1.

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