Konstantin A. Petrov, Artem I. Malomouzh, Irina V. Kovyazina, Eric Krejci, Alexandra D. Nikitashina, Svetlana E. Proskurina, Vladimir V. Zobov and Evgeny E. Nikolsky Regulation of acetylcholinesterase activity by nitric oxide in rat neuromuscular junction via N-methyl-d-aspartate receptor activation European Journal of Neuroscience 37
NO molecules depress AChE activity in the neuromuscular junction thereby enhancing endplate current amplitude. Endogenous glutamate, released into the synaptic cleft as a co-mediator of acetylcholine, is capable of triggering the NMDA receptor-/NO synthase-mediated pathway that modulates synaptic AChE activity. In addition to well-established modes of synaptic plasticity another mechanism exists based on the prompt regulation of AChE activity.
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