Francesca Inverardi, Maia Chikhladze, Andrea Donzelli, Ramona Frida Moroni, Maria Cristina Regondi, Paolo Pennacchio, Ileana Zucca, Irene Corradini, Daniela Braida, Mariaelvina Sala, Silvana Franceschetti and Carolina Frassoni Cytoarchitectural, behavioural and neurophysiological dysfunctions in the BCNU-treated rat model of cortical dysplasia European Journal of Neuroscience 37
Article first published online: 25 OCT 2012 | DOI: 10.1111/ejn.12032
Prenatal developmental insults at the peak of cortical neurogenesis induce in adult BCNU-treated rats cortical and hippocampal lesions associated with a severe impairment of spatial working memory. It also induced distortions in the basic mechanisms of plasticity in the hippocampal formation, and signs of hyperexcitability. These results may help to clarify the pathophysiological mechanisms of cognitive dysfunction that is often associated with epilepsy in patients with CD.
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