Andreas Heuer, Gaynor A. Smith and Stephen B. Dunnett Comparison of 6-hydroxydopamine lesions of the substantia nigra and the medial forebrain bundle on a lateralised choice reaction time task in mice European Journal of Neuroscience 37
Unilateral 6-hydroxydopamine lesions to either the substantia nigra or the medial forebrain bundle leads to impairments in a choice reaction time task in mice. The deficits include increased reaction and movement time latencies as well as a reduction in the number of trials attempted and response accuracy. The lesion induced deficits were stable over the weeks of testing. Operant assessment of 6-OHDA mouse models will be useful for the assessment of cell based therapies in the near future.
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