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Yonwoo Jung, Patrick J. Mulholland, Shari L. Wiseman, L. Judson Chandler and Marina R. Picciotto Constitutive knockout of the membrane cytoskeleton protein beta adducin decreases mushroom spine density in the nucleus accumbens but does not prevent spine remodeling in response to cocaine European Journal of Neuroscience 37

Article first published online: 29 OCT 2012 | DOI: 10.1111/ejn.12037

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The adducins associate with the actin cytoskeleton and are involved in synaptic plasticity. We show here that β adducin is required for stabilising mature spines under basal conditions in the nucleus accumbens, but that lack of this protein does not prevent synaptic remodeling following repeated cocaine administration. These data are consistent with previous studies suggesting that β adducin may normally be involved in stabilising spines once drug- or experience-dependent remodeling has occurred.

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