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Benjamin N. Greenwood, Katie G. Spence, Danielle M. Crevling, Peter J. Clark, Wendy C. Craig and Monika Fleshner Exercise-induced stress resistance is independent of exercise controllability and the medial prefrontal cortex European Journal of Neuroscience 37

Version of Record online: 4 NOV 2012 | DOI: 10.1111/ejn.12044

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Controllability of exercise was manipulated in rats using a novel forced wheel running paradigm closely resembling the pattern of voluntary exercise. Both voluntary and forced exercise prevented the behavioral effects of stress independently of the prefrontal cortex, a region sensitive to controllable experiences. These data suggest that exercise controllability is not a factor critical for conferring exercise-induced stress resistance, and that forced exercise may still benefit mental health.

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