Céline Melin, Florian Jacquot, Radhouane Dallel and Alain Artola Segmental disinhibition suppresses C-fiber inputs to the rat superficial medullary dorsal horn via the activation of GABAB receptors European Journal of Neuroscience 37
Blocking glycine and/or GABA(A) receptors in the medullary dorsal horn (MDH) strongly facilitates Aβ- and Aδ-fiber-evoked polysynaptic field potentials but, conversely, inhibits C-fiber ones. Suppression of C-fiber field potentials is prevented by blocking segmental GABA(B) receptors. Activation of A-fiber primary afferents might thus inhibit C-fiber inputs to the MDH through polysynaptic excitatory pathways, last-order GABAergic interneurons and presynaptic GABA(B) receptors on C-fiber terminals.
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