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Hiroshi Todaka, Tetsuya Tatsukawa, Tsutomu Hashikawa, Yuchio Yanagawa, Katsuei Shibuki and Soichi Nagao Heterotrimeric guanosine triphosphate-binding protein-coupled modulatory actions of motilin on K+ channels and postsynaptic γ-aminobutyric acid receptors in mouse medial vestibular nuclear neurons European Journal of Neuroscience 37

Article first published online: 9 NOV 2012 | DOI: 10.1111/ejn.12051

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Motilin, the gastroenteric hormone, decreases the discharge frequencies of action potentials and enhances IPSC amplitudes in a group of medial vestibular nuclear neurons by modulating the postsynaptic SK-channels and GABA-A receptors, respectively. These motilin actions are mediated through GPCR. Motilin may be co-released with GABA from floccular Purkinje cell axon terminals to affect the activity of postsynaptic medial vestibular neurons which relay the ocular reflexes.

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