Satoru Arata, Tomoya Nakamachi, Hiroshi Onimaru, Hitoshi Hashimoto and Seiji Shioda Impaired response to hypoxia in the respiratory center is a major cause of neonatal death of the PACAP-knockout mouse European Journal of Neuroscience 37
We report on the presence of abnormal respiratory activity in PACAP−/− mice under hypoxic conditions, which provides a basis for the SIDS-like phenotype. Figure shows effect of hypoxia on respiratory activity in PACAP-deficient mice. Respiration activities under either hypoxic (5% O2) or hypercapnic conditions (8% CO2) were compared to that of normoxia by plethysmography at P7. Note that hypoxia caused respiratory arrest in PACAP−/− mice.
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