Stephen B. McHugh, Andre Marques-Smith, Jennifer Li, J. N. P. Rawlins, John Lowry, Michael Conway, Gary Gilmour, Mark Tricklebank and David M. Bannerman Hemodynamic responses in amygdala and hippocampus distinguish between aversive and neutral cues during Pavlovian fear conditioning in behaving rats European Journal of Neuroscience 37
Amygdala and hippocampal tissue oxygen (TO2) signals were recorded from freely-moving rats during discriminative Pavlovian fear conditioning. TO2 signals provide a close surrogate for the BOLD-fMRI signal. TO2 signals in both regions discriminated between conditioned aversive (CS+) and neutral (CS−) cues. These data challenge recent claims that hemodynamic signals cannot detect the different patterns of neuronal activity evoked by CS+ vs. CS− stimuli.
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