Philipp Daiber, Federica Genovese, Valentin A. Schriever, Thomas Hummel, Frank Möhrlen and Stephan Frings Neuropeptide receptors provide a signalling pathway for trigeminal modulation of olfactory transduction European Journal of Neuroscience 37
Co-stimulation with an irritant attenuates odour perception. This can be shown with the floral odorant PEA and the irritant CO2 in human subjects. The effect is recapitulated in the rat olfactory system when the trigeminal peptide CGRP is co-applied with PEA. This phenomenon is the result of a modulatory interaction between the olfactory and trigeminal systems in the nose. It is mediated by neuropeptide receptors expressed by olfactory receptor neurons.
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