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Zisis Bimpisidis, Maria Antonietta De Luca, Augusta Pisanu and Gaetano Di Chiara Lesion of medial prefrontal dopamine terminals abolishes habituation of accumbens shell dopamine responsiveness to taste stimuli European Journal of Neuroscience 37

Version of Record online: 6 DEC 2012 | DOI: 10.1111/ejn.12068

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In this study we tested the hypothesis of an inhibitory influence of mPFC DA on NAc DA. We investigated by in vivo microdialysis the effect of mPFC 6-OHDA lesions on the NAc DA response to taste stimuli. The main finding of the study is that 6-OHDA lesions of the mPFC alter NAc DA responsiveness to gustatory stimuli. In particular, mPFC 6-OHDA lesions abolished one trial habituation of NAc shell DA response to taste.

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