Dominique Chesnoy-Marchais Bicuculline- and neurosteroid-sensitive tonic chloride current in rat hypoglossal motoneurons and atypical dual effect of SR95531 European Journal of Neuroscience 37
Hypoglossal motoneurons patch-clamp recordings revealed a bicuculline-sensitive tonic current, which can be enhanced by an agonist of extrasynaptic GABAA receptors and by neurosteroids, supporting previous evidence for a bicuculline-sensitive tonic inhibition. The GABAA antagonist SR95531 blocks this current but also activates another sustained anionic current, bicuculline-resistant and sensitive to a GABAC antagonist. These results reveal new targets for the protection of these fragile neurons.
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