E-mail a Wiley Online Library Link

Dominique Chesnoy-Marchais Bicuculline- and neurosteroid-sensitive tonic chloride current in rat hypoglossal motoneurons and atypical dual effect of SR95531 European Journal of Neuroscience 37

Version of Record online: 29 NOV 2012 | DOI: 10.1111/ejn.12074

Thumbnail image of graphical abstract

Hypoglossal motoneurons patch-clamp recordings revealed a bicuculline-sensitive tonic current, which can be enhanced by an agonist of extrasynaptic GABAA receptors and by neurosteroids, supporting previous evidence for a bicuculline-sensitive tonic inhibition. The GABAA antagonist SR95531 blocks this current but also activates another sustained anionic current, bicuculline-resistant and sensitive to a GABAC antagonist. These results reveal new targets for the protection of these fragile neurons.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field