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Issei Kawakita, Motokazu Uchigashima, Kohtarou Konno, Taisuke Miyazaki, Miwako Yamasaki and Masahiko Watanabe Type 2 K+–Cl− cotransporter is preferentially recruited to climbing fiber synapses during development and the stellate cell-targeting dendritic zone at adulthood in cerebellar Purkinje cells European Journal of Neuroscience 37

Article first published online: 6 DEC 2012 | DOI: 10.1111/ejn.12076

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Postnatal expression of type-2 K+-Cl cotransporter (KCC2) in neurons lowers the Cl equilibrium potential to values more negative than the resting potential, thereby converting the action of Cl-permeable GABAA and glycine receptors from excitatory to inhibitory. In the present study, we investigated spatiotemporal expression of KCC2 in mouse cerebella, particularly focusing on Purkinje cells (PCs).

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