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Brooke E. Schmeichel and Craig W. Berridge Wake-promoting actions of noradrenergic α1- and β-receptors within the lateral hypothalamic area European Journal of Neuroscience 37

Article first published online: 18 DEC 2012 | DOI: 10.1111/ejn.12084

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Central norepinephrine exerts potent wake-promoting effects, in part, through the actions of noradrenergic α1- and β-receptors located in the medial septal and medial preoptic areas. The lateral hypothalamic area (LHA), including the lateral hypothalamus, perifornical area and adjacent dorsomedial hypothalamus, is implicated in the regulation of arousal and receives a moderate noradrenergic innervation. The current studies demonstrate that noradrenergic a1- and B-receptors within the LHA promote waking in the absence of an activation of hypocretin neurons as measured by Fos immunoreactivity.

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