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Noppamas Pipatpiboon, Hiranya Pintana, Wasana Pratchayasakul, Nipon Chattipakorn and Siriporn C. Chattipakorn DPP4-inhibitor improves neuronal insulin receptor function, brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption European Journal of Neuroscience 37

Article first published online: 12 DEC 2012 | DOI: 10.1111/ejn.12088

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High fat diet (HFD) consumption has been demonstrated to cause peripheral and neuronal insulin resistance, and brain mitochondrial dysfunction in rats. Although the dipeptidyl peptidase-4 (DDP-4) inhibitor, vildagliptin, is known to improve peripheral insulin sensitivity, its effects on neuronal insulin resistance and brain mitochondrial dysfunction caused by a HFD are unknown.

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