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Philippe Huot, Tom H. Johnston, Tessa Snoeren, James B. Koprich, Michael P. Hill, Susan H. Fox and Jonathan M. Brotchie Use of catechol-O-methyltransferase inhibition to minimize L-3,4-dihydroxyphenylalanine-induced dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque European Journal of Neuroscience 37

Version of Record online: 3 JAN 2013 | DOI: 10.1111/ejn.12093

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This study was conducted in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease. The animals were administered entacapone in combination with a low, sub-threshold, dose of L-3,4-dihydroxyphenylalanine (L-DOPA), as well as a standard, higher, dose of L-DOPA, alone. The combination of entacapone and low dose L-DOPA led to a reversal of parkinsonism comparable to that achieved with a high dose of L-DOPA, while eliciting significantly less dyskinesia.

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