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Sophie A. George, Dayan Knox, Andre L. Curtis, J. Wayne Aldridge, Rita J. Valentino and Israel Liberzon Altered locus coeruleus–norepinephrine function following single prolonged stress European Journal of Neuroscience 37

Article first published online: 20 DEC 2012 | DOI: 10.1111/ejn.12095

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Single unit activity of LC neurons and TH mRNA levels were measured in the Single Prolonged Stress model of Post-traumatic stress disorder. SPS decreased rates of spontaneous discharge, exaggerated phasic responses of LC neurons and augmented stress-enhanced TH mRNA expression. These data demonstrate sustained LC-NE system abnormalities in SPS, providing an opportunity to study the interaction between LC-NE system, and other PTSD-like physiological and behavioral changes seen in this model.

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