Laurie Sellings, Schreiber Pereira, Cheng Qian, Thomas Dixon-McDougall, Christina Nowak, Bin Zhao, Rachel F. Tyndale and Derek van der Kooy Nicotine-motivated behavior in Caenorhabditis elegans requires the nicotinic acetylcholine receptor subunits acr-5 and acr-15 European Journal of Neuroscience 37
We provide evidence for nicotine reward in Caenorhabditis elegans, dependent on both dopamine and acetylcholine signaling. Caenorhabditis elegans both approaches a point source of nicotine and exhibits preference for sodium, chloride, or butanone previously paired with nicotine, independent from nicotine's locomotor effects. Caenorhabditis elegans may serve as a useful model organism that could aid in the identification of novel nicotine motivational molecular pathways and consequently the development of novel smoking cessation aids.
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