Lichao Chen, James T. McKenna, Yunren Bolortuya, Ritchie E. Brown and Robert W. McCarley Knockdown of orexin type 2 receptor in the lateral pontomesencephalic tegmentum of rats increases REM sleep European Journal of Neuroscience 37
Dysfunction of the orexin/hypocretin neurotransmitter system causes the sleep disorder narcolepsy, characterized by intrusion of rapid-eye-movement (REM) sleep-like events into normal wakefulness. The sites where orexins act to suppress REM sleep are incompletely understood. Our results indicate that removal of OxR2 neurotransmission in the lPMT enhances REM sleep by increasing the duration of REM episodes.
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