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Ouafa Ait-Hmyed, Marie-Paule Felder-Schmittbuhl, Marina Garcia-Garrido, Susanne Beck, Christina Seide, Vithiyanjali Sothilingam, Naoyuki Tanimoto, Mathias Seeliger, Mohammed Bennis and David Hicks Mice lacking Period 1 and Period 2 circadian clock genes exhibit blue cone photoreceptor defects European Journal of Neuroscience 37

Version of Record online: 25 JAN 2013 | DOI: 10.1111/ejn.12103

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Many aspects of retinal physiology are modulated by circadian clocks, but it is unclear whether clock malfunction impinges directly on photoreceptor survival, differentiation or function. Eyes from wild-type and Period1 (Per1) and Period2 (Per2) mutant mice (Per1Brdm1Per2Brdm1) were examined for structural (histology, in vivo fundus imaging), phenotypical (RNA expression, immunohistochemistry) and functional (electrophysiology) characteristics.

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