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Zoltán Rusznák, Balázs Pál, Áron Kőszeghy, Yuhong Fu, Géza Szücs and George Paxinos The hyperpolarization-activated non-specific cation current (Ih) adjusts the membrane properties, excitability, and activity pattern of the giant cells in the rat dorsal cochlear nucleus European Journal of Neuroscience 37

Article first published online: 10 JAN 2013 | DOI: 10.1111/ejn.12116

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Giant cells of the rat dorsal cochlear nucleus possess the hyperpolarization-activated non-specific cation current (Ih). HCN1, HCN2, and HCN4 subunits may all contribute to the assembly of the functional channels. Inhibition of Ih induces hyperpolarization, reduces the frequency of spontaneous biphasic postsynaptic currents, and increases the decay time constants of the inhibitory component. Ih also contributes to the intrinsic activity of spontaneously active giant cells.

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