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Jason B. Carmel, Hiroki Kimura, Lauren J. Berrol and John H. Martin Motor cortex electrical stimulation promotes axon outgrowth to brain stem and spinal targets that control the forelimb impaired by unilateral corticospinal injury European Journal of Neuroscience 37

Version of Record online: 29 JAN 2013 | DOI: 10.1111/ejn.12119

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We tested whether electrical stimulation of the intact corticospinal tract after unilateral injury promoted outgrowth of axon terminations arising from forelimb area of motor cortex. In all motor cortex targets that we measured, axon termination length was 2–5 times greater in rats with injury and stimulation than with injury only controls. In the magnocellular red nucleus and the cervical spinal cord axon outgrowth was also targeted to areas important for motor control of the impaired forelimb.

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