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Mardi S. Byerly, Muhannad Al Salayta, Roy D. Swanson, Kiwook Kwon, Jonathan M. Peterson, Zhikui Wei, Susan Aja, Timothy H. Moran, Seth Blackshaw and G. William Wong Estrogen-related receptor β deletion modulates whole-body energy balance via estrogen-related receptor γ and attenuates neuropeptide Y gene expression European Journal of Neuroscience 37

Article first published online: 29 JAN 2013 | DOI: 10.1111/ejn.12122

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Selective reduction of Estrogen-related receptor β (ERRβ) expression in the CNS resulted in an increased ratio of ERRγ gene expression relative to ERRβ, decreased NPY gene expression in the hindbrain, significantly decreased intermeal interval and satiety, and enhanced body weight, lean mass, insulin sensitivity, and whole-body energy metabolism. These data support the hypothesis that an extra-hypothalamic site, such as the hindbrain, can modulate peripheral tissue metabolism and food intake.

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