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Huiyuan Zheng and Linda Rinaman Yohimbine anxiogenesis in the elevated plus maze requires hindbrain noradrenergic neurons that target the anterior ventrolateral bed nucleus of the stria terminalis European Journal of Neuroscience 37

Article first published online: 1 FEB 2013 | DOI: 10.1111/ejn.12123

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The α2 adrenergic receptor antagonist yohimbine (YO) increases transmitter release from noradrenergic (NA) terminals in cortical and subcortical brain regions, including the bed nucleus of the stria terminalis (BST). YO activates the HPA stress axis and is potently anxiogenic in rats and humans.

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