Kevan A. C. Martin and Isabelle A. Spühler The fine structure of the dopaminergic innervation of area 10 of macaque prefrontal cortex European Journal of Neuroscience 37
In this study we examined dopaminergic axons in prefrontal Area 10 of macaque monkey. Boutons containing vesicles and axonal segments were examined using electron microscopy in long series of sections, but synapses were rare. Boutons were randomly distributed and nearest neighbours were separated by ~9 μm in 3-D. Our anatomical observations support the hypothesis of a non-synaptic release of dopamine into the extracellular space, thus broadcasting a signal to receptors distributed anywhere across the cortical neuropil.
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