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Elizabeth W. Mayne, Michael T. Craig, Chris J. McBain and Ole Paulsen Dopamine suppresses persistent network activity via D1-like dopamine receptors in rat medial entorhinal cortex European Journal of Neuroscience 37

Article first published online: 22 JAN 2013 | DOI: 10.1111/ejn.12125

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Cortical neurons show persistent activity in the form of active ‘UP’ states punctuated by quiescent ‘DOWN’ states, a phenomenon linked to working memory. UP states are generated by fast excitatory and inhibitory synaptic transmission, but how they are affected by neuromodulators has been less studied. Here we show that dopamine, also implicated in working memory, can strongly and reversibly suppress persistent activity via a mechanism involving D1-like dopamine receptors.

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