Kazuhiro Sano, Mumeko C. Tsuda, Sergei Musatov, Toshiro Sakamoto and Sonoko Ogawa Differential effects of site-specific knockdown of estrogen receptor α in the medial amygdala, medial pre-optic area, and ventromedial nucleus of the hypothalamus on sexual and aggressive behavior of male mice European Journal of Neuroscience 37
We found that knocking down of ERα using AAV-shERα in the MPOA reduced sexual but not aggressive behavior while that in the VMN reduced both behaviors in gonadally intact adult male mice. Knockdown of ERα in the MeA did not alter either behavior. These results indicate that ERα in both the MPOA and VMN is required for testosterone to facilitate male sexual behavior, whereas ERα only in the VMN is required for testosterone to facilitate male aggressive behavior among these three brain regions.
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