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Gabriela M. Rozanski, Qi Li and Elise F. Stanley Transglial transmission at the dorsal root ganglion sandwich synapse: glial cell to postsynaptic neuron communication European Journal of Neuroscience 37

Article first published online: 25 JAN 2013 | DOI: 10.1111/ejn.12132

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The DRG contains a subset of neuronal somata ‘Sandwich Synapse’ pairs separated by single glial membrane septum. Stimulation of one soma triggers a delayed response in its pair (EJN 2012a) via a bi-synaptic, neuron-glia-neuron pathway (diagram). Neuron-to-glial transmission is purinergic via P2Y2 receptors (EJN 2012b). Here we show the glial-to-neuron synapse is glutamatergic via NMDA receptors and is blocked by AP3 or ifenprodil (lower panel), completing the synaptic pathway.

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