Jean-François Poulin, Patrick Bérubé, Sylvie Laforest and Guy Drolet Enkephalin knockdown in the central amygdala nucleus reduces unconditioned fear and anxiety European Journal of Neuroscience 37
ENK are highly expressed in the CeA where several lines of evidence point to a potential role in the modulation of fear and anxiety. ENK knockdown in this region by using a lentiviral expressing shRNA reduced anxiety-like behaviors in the elevated plus maze. In the contextual fear paradigm, a reduction in freezing during the acquisition phase was also observed in knockdown animals, with no effect on the retention of the conditioned response.
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