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Jean-François Poulin, Patrick Bérubé, Sylvie Laforest and Guy Drolet Enkephalin knockdown in the central amygdala nucleus reduces unconditioned fear and anxiety European Journal of Neuroscience 37

Version of Record online: 1 FEB 2013 | DOI: 10.1111/ejn.12134

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ENK are highly expressed in the CeA where several lines of evidence point to a potential role in the modulation of fear and anxiety. ENK knockdown in this region by using a lentiviral expressing shRNA reduced anxiety-like behaviors in the elevated plus maze. In the contextual fear paradigm, a reduction in freezing during the acquisition phase was also observed in knockdown animals, with no effect on the retention of the conditioned response.

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