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L. E. Ramos-Languren and M. L. Escobar Plasticity and metaplasticity of adult rat hippocampal mossy fibers induced by neurotrophin-3 European Journal of Neuroscience 37

Article first published online: 7 FEB 2013 | DOI: 10.1111/ejn.12141

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During the last decade, neurotrophin-3 (NT-3) has emerged as one potent mediator of synaptic plasticity. Here, we show that intrahippocampal microinfusion of NT-3 induces a long-lasting potentiation of synaptic efficacy in the DG-CA3 projection accompanied by a MF structural reorganization of adult rats in vivo. Furthermore, NT-3 modifies the ability of the MF pathway to present subsequent LTP by HFS, and modifies the structural reorganization pattern.

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