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Maria B. Goncalves, Earl Clarke, Carl Hobbs, Tony Malmqvist, Robert Deacon, Julian Jack and Jonathan P. T. Corcoran Amyloid β inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonist European Journal of Neuroscience 37

Version of Record online: 4 FEB 2013 | DOI: 10.1111/ejn.12142

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The Retinoic Acid Receptor (RAR) α system plays a key role in the adult brain, participating in the homeostatic control of synaptic plasticity, essential for memory function. Here we show that RARα signalling is down regulated by amyloid beta (Aβ), which inhibits the synthesis of the endogenous ligand, retinoic acid (RA).

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