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Luiz F. Ferrari, Emma Levine and Jon D. Levine Role of a novel nociceptor autocrine mechanism in chronic pain European Journal of Neuroscience 37

Article first published online: 4 FEB 2013 | DOI: 10.1111/ejn.12145

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Intradermal injection of PGE2 induces a PKA-dependent short-term hyperalgesia. However, in a model of chronic pain, hyperalgesic priming, produced by a previous inflammatory stimulus, PGE2 hyperalgesia is prolonged; in addition to PKA, there is now a late, PKCε-dependent, component. We provide evidence that the extracellular cAMP-adenosine pathway, in the peripheral terminal of the nociceptor, is the underlying mechanism for the delayed PKCε-dependent hyperalgesia.

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