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Akihiro Kimura, Satoshi Shimegi, Shin'ichiro Hara, Masahiro Okamoto and Hiromichi Sato Role of GABAergic inhibition in shaping the spatial frequency tuning of neurons and its contrast dependency in the dorsal lateral geniculate nucleus of cat European Journal of Neuroscience 37

Version of Record online: 13 FEB 2013 | DOI: 10.1111/ejn.12149

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To understand how GABAergic inhibition contributes to the elaboration of spatial frequency (SF) tuning of neurons in the lateral geniculate nucleus (LGN), we examined the effects of microiontophoretic administration of bicuculline methiodide (BIC) and gabazine, both antagonists of GABAA receptors, on visual responses to grating stimuli with high or low contrasts. BIC administration changed the shape of the SF tuning curve of the spike response from band-pass to low-pass.

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