Andreas Heuer, Ngoc-Nga Vinh and Stephen B. Dunnett Behavioural recovery on simple and complex tasks by means of cell replacement therapy in unilateral 6-hydroxydopamine-lesioned mice European Journal of Neuroscience 37
Unilateral 6-hydroxydopamine lesions to the medial forebrain bundle cause impairments on simple behavioural tests and the lateralised choice reaction time task conducted in the 9-hole operant box. Dopamine-rich primary fetal tissue grafts were able to ameliorate the lesion-induced deficits on some but not all parameters. The behavioural tests presented are useful drug-free approaches for evaluating cell based therapies.
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