Emily B. Einstein, Yukiko Asaka, Mark F. Yeckel, Michael J. Higley and Marina R. Picciotto Galanin-induced decreases in nucleus accumbens/striatum excitatory postsynaptic potentials and morphine conditioned place preference require both galanin receptor 1 and galanin receptor 2 European Journal of Neuroscience 37
Galanin modulates morphine's behavioral effects in mice. This study identifies direct actions on excitation of striatal neurons and identifies the galanin receptor (GalR) subtypes involved. Galanin decreases the amplitude of excitatory postsynaptic potentials in medium spiny neurons of wild type mice, but not mice lacking the GalR1 or GalR2 subtype. Neither GalR1 nor GalR2 knockout mice exhibit conditioned place preference for morphine. Thus both phenotypes depend on GalR1 and GalR2.
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