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Linda C. Jansson, Lauri Louhivuori, Henna-Kaisa Wigren, Tommy Nordström, Verna Louhivuori, Maija L. Castrén and Karl E. Åkerman Effect of glutamate receptor antagonists on migrating neural progenitor cells European Journal of Neuroscience 37

Version of Record online: 6 FEB 2013 | DOI: 10.1111/ejn.12152

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In neurosphere-derived migrating cells metabotropic glutamate receptor 5 dominates in radial glial cell and its inhibition reduces the length of radial processes and causes enhanced motility and forward progress of neurons and reduces changes in direction. AMPA receptors are mainly present in neurons and their inhibition severely reduces the forward motion of neurons but enhances the extension of radial processes.

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