Ann Chi Yan Wong, Lutz Birnbaumer and Gary D. Housley Canonical transient receptor potential channel subtype 3-mediated hair cell Ca2+ entry regulates sound transduction and auditory neurotransmission European Journal of Neuroscience 37
Ca2+ microfluorimetry indicated that cochlear hair cells lacking the TRPC3 ion channel subunit had significantly reduced Ca2+ entry to balance cytosolic Ca2+ depletion via PMCA2a Ca2+ pumps. Thus hair cell cytosolic Ca2+ homeostasis was disrupted, likely affecting membrane conductance and sound transduction. This postulate was supported by enhanced hearing sensitivity (hyperacusis) in the TRPC3 knockout mice, determined by auditory brainstem response and distortion product otoacoustic emission.
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