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Fei Liu, Zhi-Qin Xue, Si-Hao Deng, Xiong Kun, Xue-Gang Luo, Peter R. Patrylo, Gregory M. Rose, Huaibin Cai, Robert G. Struble, Yan Cai and Xiao-Xin Yan γ-Secretase binding sites in aged and Alzheimer's disease human cerebrum: the choroid plexus as a putative origin of CSF Aβ European Journal of Neuroscience 37

Article first published online: 22 FEB 2013 | DOI: 10.1111/ejn.12159

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Deposition of β -amyloid (Aβ) peptides, cleavage products of β-amyloid precursor protein (APP) by β-secretase-1 (BACE1) and γ-secretase, is a neuropathological hallmark of Alzheimer's disease (AD). γ-Secretase inhibition is a therapeutic anti-Aβ approach, although it is unclear whether the enzyme's activity is altered in AD brain.

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