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Sarah Beggiato, Tiziana Antonelli, Maria Cristina Tomasini, Sergio Tanganelli, Kjell Fuxe, Robert Schwarcz and Luca Ferraro Kynurenic acid, by targeting α7 nicotinic acetylcholine receptors, modulates extracellular GABA levels in the rat striatum in vivo European Journal of Neuroscience 37

Version of Record online: 26 FEB 2013 | DOI: 10.1111/ejn.12160

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Kynurenic acid (KYNA) is an astrocyte-derived, non-competitive antagonist of the α7 nicotinic acetylcholine receptor (α7nAChR) and inhibits the NMDA receptor (NMDAR) competitively. The present in vivo microdialysis study provides evidence that fluctuations in endogenous KYNA levels tonically modulate extracellular glutamate and GABA levels in the rat striatum, mainly by acting on α7nAChRs. This effects may be relevant for a number of physiological and pathological processes involving the basal ganglia.

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