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Li-Mei Wang, Yong-Jiu Wang, Min Cui, Wen-Juan Luo, Xiao-Ji Wang, Philip A. Barber and Zhe-Yu Chen A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia European Journal of Neuroscience 37

Article first published online: 5 MAR 2013 | DOI: 10.1111/ejn.12162

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Resveratrol (RSV) administration significantly reduced infarct volumes, improved behavioral, increased AMPK and SIRT1activities and decreased energy assumption and restored cell energy ATP level in recurrent ischemic stroke models. RSV provides neuroprotection in recurrent stroke models by regulating the AMPK and SIRT1 signaling thereby reducing energy requirements during ischemia.

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