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Lara Eid, Marie-France Champigny, André Parent and Martin Parent Quantitative and ultrastructural study of serotonin innervation of the globus pallidus in squirrel monkeys European Journal of Neuroscience 37

Article first published online: 25 FEB 2013 | DOI: 10.1111/ejn.12164

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Unbiased examination of 5-HT axon varicosities in GPi and GPe of squirrel monkey indicates a decreasing anteroposterior gradient. Less than 25% of 5-HT varicosities display a synaptic contact, exclusively found on pallidal dendrites, indicating that 5-HT exerts its modulatory effect upon pallidal afferents mainly through diffuse transmission, whereas its direct control of pallidal neurons results from both synaptic and diffuse transmission.

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